Evaluation of serum levels of iron, total iron binding capacity, transferrin saturation and ferritin in chronic kidney disease patients vs. control group

  • Hafsatu Maiwada Suleiman | suleimanhafsatu@yahoo.com Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
  • Mohammed Amina Federal Medical Centre, Bida, Nigeria.
  • Ibrahim Abubakar Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
  • Yusuf Rasheed Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
  • Mohammed Jibril El-Bashir Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
  • Mohammed Manu Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
  • Bello Jamoh Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
  • Amina Dogara Bashir Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

Abstract

The magnitude of chronic renal disease is enormous, as the prevalence of kidney failure is rising. Anaemia is a common complication of chronic kidney disease (CKD) that develops early in its course and becomes increasingly severe as the disease progresses. The aim is to evaluate the serum level of iron, Total Iron Binding Capacity (TIBC), transferrin saturation and ferritin in chronic kidney disease population in Zaria and control subjects. This study was conducted at ABUTH Zaria were 125 patients in various stages of CKD who presented at the nephrology clinic and equal number of apparently healthy age and sex matched controls were recruited. The mean (SD) age of patient and controls were 48 (14) years. These were made up of 53.6% males, and 46.4% females. Mean values of serum creatinine significantly higher in the patients (<0.0001). There was no significant difference in the mean values of iron (p=0.32) and TIBC (p=1.29) in both study groups. The patients had a significantly (p˂0.0001) higher mean value for ferritin and TSAT than the control group. There were higher serum creatinine and ferritin values in males than in females while higher serum TIBC, estimated creatinine clearance and iron were observed in females than males. Serum creatinine, ferritin and estimated creatinine clearance of male patients were found to be significantly higher with p-value of 0.002, 0.000 and 0.028 respectively than that of female patients. No significant differences were noted in serum levels of iron, TIBC and TSAT. Serum creatinine, ferritin and TSAT were found to be significantly elevated in CKD patients while serum Iron and TIBC were not.

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Published
2020-03-17
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Keywords:
Chronic kidney disease, Total iron binding capacity, Transferrin Saturation, Ferritin, Estimated GFR
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How to Cite
Suleiman, Hafsatu Maiwada, Mohammed Amina, Ibrahim Abubakar, Yusuf Rasheed, Mohammed Jibril El-Bashir, Mohammed Manu, Bello Jamoh, and Amina Dogara Bashir. 2020. “Evaluation of Serum Levels of Iron, Total Iron Binding Capacity, Transferrin Saturation and Ferritin in Chronic Kidney Disease Patients Vs. Control Group”. Annals of African Medical Research 2 (2). https://doi.org/10.4081/aamr.2019.101.